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By Committee on Predictive-Toxicology Approaches for Military Assessments of Acute Exposures,Board on Environmental Studies and Toxicology,Board on Life Sciences,Division on Earth and Life Studies,and Medicine The National Academies of Sciences Engineering

The US division of safeguard (DOD) is confronted with an overpowering activity in comparing chemical substances that can in all probability pose a possibility to its deployed team of workers. There are over 84,000 registered chemical substances, and trying out them with conventional toxicity-testing equipment isn't possible by way of time or cash. lately, there was a concerted attempt to boost new techniques to toxicity trying out that comprise advances in platforms biology, toxicogenomics, bioinformatics, and computational toxicology. Given the advances, DOD requested the nationwide learn Council to figure out how DOD may well use glossy techniques for predicting chemical toxicity in its efforts to avoid debilitating, acute exposures to deployed group of workers. This document offers an total conceptual process that DOD might use to strengthen a predictive toxicology procedure. Application of recent Toxicology techniques for Predicting Acute Toxicity for Chemical Defense stories the present nation of computational and high-throughput methods for predicting acute toxicity and indicates tools for integrating info and predictions. This record concludes with classes discovered from present high-throughput screening courses and indicates a few preliminary steps for DOD investment.

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Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense by Committee on Predictive-Toxicology Approaches for Military Assessments of Acute Exposures,Board on Environmental Studies and Toxicology,Board on Life Sciences,Division on Earth and Life Studies,and Medicine The National Academies of Sciences Engineering


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